This is a famous painting by Jean Fouquet which dates from about 1453. It's yet another version of the virgin and child, but this time the model for the virgin is assumed to be one Agnès Sorel, the favorite mistress of King Charles VII. The original painting hangs in the Musée des Beaux Arts in Antwerp, Belgium. This copy is in the Renaissance château at Loches.
Sorel died suddenly in 1450 at the age of twenty-eight. Her body lies in the church of St.-Ours in Loches, while her heart is entombed at Jumièges in Normandy. Apparently her remains were exhumed in 2004 for an autopsy, which revealed a large dose of mercury in her system. This discovery all but confirmed the historical suspicion that Agnès was intentionally poisoned, but there is still much doubt as to who her murderer was.
I took this photo of the painting in Loches. I cropped out some shadows around the edges of the image, so there is a little bit of the painting missing.